منابع مشابه
RGS proteins: new players in the field of opioid signaling and tolerance mechanisms.
In this article we review recent advances in our understanding of the crucial role of the Regulator of G protein Signaling (RGS) proteins in opioid signaling mechanisms and opioid tolerance development. Opioids exert their physiologic effects via complex G protein-coupled receptor-signaling mechanisms, and RGS proteins are now known to tightly regulate the G protein signaling cycle. RGS protein...
متن کاملRGS proteins inhibit Xwnt-8 signaling
Heterotrimeric GTP-binding proteins (G proteins) are intracellular signaling molecules that are activated by seven transmembrane receptors (Gilman, 1987; Hamm and Gilchrist, 1996; Neer, 1995). Heterotrimeric G proteins are composed of α, β and γ subunits and there are multiple types of each subunit. Seven transmembrane receptors for hormones, cytokines and other agonists have guanine nucleotide...
متن کاملGTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.
GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by increasing the rates at which their subunits hydrolyze bound GTP and thus return to the inactive state. G protein GAPs act allosterically on G subunits, in contrast to GAPs for the Ras-like monomeric GTP-binding proteins. Although they do not contribute directly to the chemistry of GTP hydrolysis, G protein GAPs can acceler...
متن کاملAddictive drugs modulate GIRK-channel signaling by regulating RGS proteins.
Regulator of G-protein signaling (RGS) proteins are strong modulators of G-protein-mediated pathways in the nervous system. One function of RGS proteins is to accelerate the activation-deactivation kinetics of G-protein-coupled inwardly rectifying potassium (GIRK) channels. The opening of GIRK channels reduces the firing rates of neurons. Recent studies indicate that RGS proteins also modulate ...
متن کاملRGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.
The intracellular regulator of G protein signalling (RGS) proteins were first identified as GTPase activating proteins (GAPs) for heterotrimeric G proteins, however, it was later found that they can also regulate G protein-effector interactions in other ways that are still not well understood. There is increasing evidence that some of the effects of RGS proteins occur due to their ability to in...
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ژورنال
عنوان ژورنال: The Korean Journal of Pain
سال: 2006
ISSN: 1226-2579
DOI: 10.3344/kjp.2006.19.1.8